Usually, only those who itemize their deductions qualify for the charitable contribution deduction, and taxpayers are also only allowed to deduct donations that are up to 60% of their AGI. However, the new $300 deduction from the CARES Act is specifically for those who don’t itemize their deductions and would typically not get any tax benefit for donations. Since it’s considered an above-the-line deduction, the IRS applies it when calculating your AGI. In other words, if you donate up to $300 in cash to a qualified organization, your AGI will be reduced by up to $300—and you can still claim the standard deduction.
Remember, the deduction only applies to cash donations made to qualified 501(c)(3) organizations. The IRS.gov site has a database with every qualified organization, which you can search to make sure your charity of choice qualifies.